Cizzle正在开发一种肺癌早筛的血液检测方法。该公司是约克大学的衍生公司，成立于2006年，基于Coverley教授及其同事的工作发现。它的概念验证原型测试是基于检测一种稳定的血浆生物标志物的能力，一种被称为CIZ1B的CIZ1变体。CIZ1是一种天然存在的参与DNA复制的细胞核蛋白，而靶向的CIZ1B变异与早期肺癌高度相关。

Cizzle Biotechnology is developing a blood test for the early detection of lung cancer. The Company is a spin- out from the University of York, founded in 2006, around the work of Professor Coverley and colleagues. Its proof-of-concept prototype test is based on the ability to detect a stable plasma biomarker, a variant of CIZ1 known as CIZ1B. CIZ1 is a naturally occurring cell nuclear protein involved in DNA replication, and the targeted CIZ1B variant is highly correlated with early-stage lung cancer.